Effect of Z19n, a synthetic compound, on Cutibacterium acnes growth and biofilm

• Main Author: Choo, Ying
• Other Authors: Scott Rice
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/143306
• Institution: Nanyang Technological University

As a chronic inflammatory skin disease of the pilosebaceous units and one of the most common skin disorders in the world, acne has affected 88% of adolescents aged 13-19 in Singapore.[1] Treatment for acne is the use of antibiotics. For mild to moderate acne, topical antibiotics are given while oral antibiotics are given to treat moderate to severe acne. Clindamycin, erythromycin and tetracycline are the most commonly used antibiotics. Due to selection pressure, the number of people that are resistant to antibiotics is increasing hence, there is an urgent need to come up with new solutions to treat acne. Z19n, a synthetic metal compound, was discovered to target a bacterium that is associated with acne. The compound was able to effectively inhibit bacterial cells in 2 days by disturbing the intracellular metal ion concentration. This study will focus on the effect of Z19n on bacterial growth and biofilm.