Photolabile linkers for solid-phase synthesis

Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendl...

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Main Authors: Mikkelsen, Remi J. T., Grier, Katja E., Mortensen, Kim T., Nielsen, Thomas E., Qvortrup, Katrine
Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/143492
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1434922020-09-04T07:21:51Z Photolabile linkers for solid-phase synthesis Mikkelsen, Remi J. T. Grier, Katja E. Mortensen, Kim T. Nielsen, Thomas E. Qvortrup, Katrine Singapore Centre for Environmental Life Sciences and Engineering Science::Biological sciences::Biochemistry Solid-phase Synthesis Photolabile Linker Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendly and appealing in the context of greener chemistry. The mild conditions also allow for applications of released material in subsequent biological screening experiments, where contamination with cleavage reagents would be detrimental. This Review pays attention to the increasing number of photolabile linkers developed for solid-phase synthesis and release and covers: (i) o-nitrobenzyloxy linkers, (ii) o-nitrobenzylamino linkers, (iii) α-substituted o-nitrobenzyl linkers, (iv) o-nitroveratryl linkers, (v) phenacyl linkers, (vi) p-alkoxyphenacyl linkers, (vii) benzoin linkers, (viii) pivaloyl linkers, and (ix) other photolabile linkers. 2020-09-04T07:17:56Z 2020-09-04T07:17:56Z 2018 Journal Article Mikkelsen, R. J. T., Grier, K. E., Mortensen, K. T., Nielsen, T. E. and Qvortrup, K. (2018). Photolabile linkers for solid-phase synthesis. ACS Combinatorial Science, 20(7), 377-399. doi: 10.1021/acscombsci.8b00028 2156-8944 https://hdl.handle.net/10356/143492 10.1021/acscombsci.8b00028 29863839 2-s2.0-85048133814 7 20 377-399 379 en ACS combinatorial science © 2018 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Biological sciences::Biochemistry
Solid-phase Synthesis
Photolabile Linker
spellingShingle Science::Biological sciences::Biochemistry
Solid-phase Synthesis
Photolabile Linker
Mikkelsen, Remi J. T.
Grier, Katja E.
Mortensen, Kim T.
Nielsen, Thomas E.
Qvortrup, Katrine
Photolabile linkers for solid-phase synthesis
description Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendly and appealing in the context of greener chemistry. The mild conditions also allow for applications of released material in subsequent biological screening experiments, where contamination with cleavage reagents would be detrimental. This Review pays attention to the increasing number of photolabile linkers developed for solid-phase synthesis and release and covers: (i) o-nitrobenzyloxy linkers, (ii) o-nitrobenzylamino linkers, (iii) α-substituted o-nitrobenzyl linkers, (iv) o-nitroveratryl linkers, (v) phenacyl linkers, (vi) p-alkoxyphenacyl linkers, (vii) benzoin linkers, (viii) pivaloyl linkers, and (ix) other photolabile linkers.
author2 Singapore Centre for Environmental Life Sciences and Engineering
author_facet Singapore Centre for Environmental Life Sciences and Engineering
Mikkelsen, Remi J. T.
Grier, Katja E.
Mortensen, Kim T.
Nielsen, Thomas E.
Qvortrup, Katrine
format Article
author Mikkelsen, Remi J. T.
Grier, Katja E.
Mortensen, Kim T.
Nielsen, Thomas E.
Qvortrup, Katrine
author_sort Mikkelsen, Remi J. T.
title Photolabile linkers for solid-phase synthesis
title_short Photolabile linkers for solid-phase synthesis
title_full Photolabile linkers for solid-phase synthesis
title_fullStr Photolabile linkers for solid-phase synthesis
title_full_unstemmed Photolabile linkers for solid-phase synthesis
title_sort photolabile linkers for solid-phase synthesis
publishDate 2020
url https://hdl.handle.net/10356/143492
_version_ 1681056599563567104