Bioinspired deamination of α-amino acid derivatives catalyzed by a palladium/nickel complex

• Main Authors: Deng, Gongtao, Chen, Jie, Sun, Wangbin, Bian, Kehan, Jiang, Yaojia, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering::Biochemical engineering; Bioinspired Reactions; C-H Activation
• Online Access: https://hdl.handle.net/10356/143699
• Institution: Nanyang Technological University

An efficient bioinspired deamination method of both natural and unnatural amino acid derivatives has been developed. This method provides easy access to a wide variety of useful α, β‐unsaturated carbonyl compounds. The reaction is realized with two transition metal catalysts (palladium and Nickel) in‐easy handling procedure. A possible reaction pathway is also proposed and the control experiments support the involvement of the palladium‐catalyzed inert sp3 C−H activation as one of the key steps.