Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair
Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels have proven to be an excellent method in research and clinical fields. However, it has been difficult to simultaneously solve three main issues in osteochondral replacement preparation: surface lubrication,...
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sg-ntu-dr.10356-1437372020-09-21T08:43:19Z Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair Yao, Hang Kang, Junpei Li, Weichang Liu, Jian Xie, Renjian Wang, Yingjun Liu, Sa Wang, Dong-An Ren, Li School of Chemical and Biomedical Engineering Engineering::Chemical engineering Hydrogels β-TCP/PVA Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels have proven to be an excellent method in research and clinical fields. However, it has been difficult to simultaneously solve three main issues in osteochondral replacement preparation: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study. Separated nano-ball milling with ultrasound dispersion prepared β-TCP demonstrated suitable properties of tiny particle size, high purity and ideal distribution, improving the mechanical properties of the novel integrated hydrogel, and providing a cartilage-like lubrication effect and high biocompatibility, including cytocompatibility and osteogenesis. The reinforcement of β-TCP and integrated molding technology enabled the hydrogel to demonstrate excellent component compatibility and good bonding between the two layers, which promoted the strengthening of the compression modulus and tensile modulus up to three times by mechanical testing. The surface lubrication properties of the novel osteochondral hydrogel were similar to the natural cartilage by friction coefficient characterization. The two layers of the novel integrated graft provided a considerable bio-function by co-culturing with chondrocytes and synovium mesenchymal stem cells: chondrocytes promoted adherence achieved by the upper density layer and better osteogenesis performance of the porous lower layer. The design of the bilayered β-TCP/PVA osteochondral hydrogel is promising for use in articular cartilage repair. 2020-09-21T08:43:19Z 2020-09-21T08:43:19Z 2017 Journal Article Yao, H., Kang, J., Li, W., Liu, J., Xie, R., Wang, Y., ... Ren, L. (2017). Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair. Biomedical Materials, 13(1), 015012-. doi:10.1088/1748-605X/aa8541 1748-605X https://hdl.handle.net/10356/143737 10.1088/1748-605X/aa8541 28792423 1 13 015012 en Biomedical Materials © 2017 IOP Publishing. All rights reserved. |
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Engineering::Chemical engineering Hydrogels β-TCP/PVA Yao, Hang Kang, Junpei Li, Weichang Liu, Jian Xie, Renjian Wang, Yingjun Liu, Sa Wang, Dong-An Ren, Li Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
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Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels have proven to be an excellent method in research and clinical fields. However, it has been difficult to simultaneously solve three main issues in osteochondral replacement preparation: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study. Separated nano-ball milling with ultrasound dispersion prepared β-TCP demonstrated suitable properties of tiny particle size, high purity and ideal distribution, improving the mechanical properties of the novel integrated hydrogel, and providing a cartilage-like lubrication effect and high biocompatibility, including cytocompatibility and osteogenesis. The reinforcement of β-TCP and integrated molding technology enabled the hydrogel to demonstrate excellent component compatibility and good bonding between the two layers, which promoted the strengthening of the compression modulus and tensile modulus up to three times by mechanical testing. The surface lubrication properties of the novel osteochondral hydrogel were similar to the natural cartilage by friction coefficient characterization. The two layers of the novel integrated graft provided a considerable bio-function by co-culturing with chondrocytes and synovium mesenchymal stem cells: chondrocytes promoted adherence achieved by the upper density layer and better osteogenesis performance of the porous lower layer. The design of the bilayered β-TCP/PVA osteochondral hydrogel is promising for use in articular cartilage repair. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Yao, Hang Kang, Junpei Li, Weichang Liu, Jian Xie, Renjian Wang, Yingjun Liu, Sa Wang, Dong-An Ren, Li |
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Article |
author |
Yao, Hang Kang, Junpei Li, Weichang Liu, Jian Xie, Renjian Wang, Yingjun Liu, Sa Wang, Dong-An Ren, Li |
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Yao, Hang |
title |
Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
title_short |
Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
title_full |
Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
title_fullStr |
Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
title_full_unstemmed |
Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
title_sort |
novel β-tcp/pva bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair |
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2020 |
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https://hdl.handle.net/10356/143737 |
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