Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch

Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch

The p53 protein, a tumour suppressor, is a key player in the DNA damage response. The activation of apoptosis by p53 involves the intrinsic apoptotic pathway to eliminate stressed cells that contain DNA lesions. Recent experiments have found that apoptosis happen in an all-or-none switch like manner...

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Bibliographic Details
Main Authors: Chong, Ket Hing, Samarasinghe, Sandhya, Kulasiri, Don, Zheng, Jie
Other Authors: School of Computer Science and Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Engineering::Computer science and engineering
p53
Apoptosis
Online Access:https://hdl.handle.net/10356/143858
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/143858

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