Expedient synthesis of E-hydrazone esters and 1H-indazole scaffolds through heterogeneous single-atom platinum catalysis

• Main Authors: Liu, Cuibo, Chen, Zhongxin, Yan, Huan, Xi, Shibo, Yam, Kah Meng, Gao, Jiajian, Du, Yonghua, Li, Jing, Zhao, Xiaoxu, Xie, Keyu, Xu, Haisen, Li, Xing, Leng, Kai, Pennycook, Stephen J., Liu, Bin, Zhang, Chun, Koh, Ming Joo, Loh, Kian Ping
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Chemical engineering; E-hydrazone Esters; 1H-indazole
• Online Access: https://hdl.handle.net/10356/144004
• Institution: Nanyang Technological University

Unprotected E-hydrazone esters are prized building blocks for the preparation of 1H-indazoles and countless other N-containing biologically active molecules. Despite previous advances, efficient and stereoselective synthesis of these compounds remains nontrivial. Here, we show that Pt single atoms a...