Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings
Nicotine has many physiological effects due to its neurotransmitter binding properties, associated with its usage as a recreational drug. Despite the great number of solution phase studies, very little has been published about gas phases spectroscopic properties. We report the first electronic spect...
Saved in:
Main Authors: | , , , |
---|---|
Other Authors: | |
Format: | Conference or Workshop Item |
Language: | English |
Published: |
2020
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/144169 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-144169 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1441692020-10-22T20:10:55Z Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings Robertson, Patrick A. Villani, Luigi Martin, Danielle Robertson, Evan G. Asian Spectroscopy Conference 2020 Institute of Advanced Studies Science::Chemistry Nicotine Analogues Molecular Conformation Nicotine has many physiological effects due to its neurotransmitter binding properties, associated with its usage as a recreational drug. Despite the great number of solution phase studies, very little has been published about gas phases spectroscopic properties. We report the first electronic spectra, obtained via two colour resonant two-photon ionisation spectroscopy. Evidence of two distinct conformers is supported by conformer specific IR-UV ion depletion spectra, interpreted with the aid of quantum chemistry calculations. Unconventional CH⋯N type hydrogen bonds between the rings play a key role in determining the conformational structures and giving rise to “blue-shift” perturbations in their IR spectra that facilitate their assignment. It is striking that the conformers are structurally very similar in the ground state, but upon excitation one of them undergoes a significant change in pyrrolidine puckering giving rise to an electronic spectrum of quite different character. Published version 2020-10-19T06:30:40Z 2020-10-19T06:30:40Z 2020 Conference Paper Robertson, P. A., Villani, L., Martin, D., & Robertson E. G. (2020). Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings. Proceedings of the 7th Asian Spectroscopy Conference 2020 (ASC 2020). doi:10.32655/ASC_8-10_Dec2020.4 https://hdl.handle.net/10356/144169 10.32655/ASC_8-10_Dec2020.4 en © 2020 Nanyang Technological University. application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
continent |
Asia |
country |
Singapore Singapore |
content_provider |
NTU Library |
collection |
DR-NTU |
language |
English |
topic |
Science::Chemistry Nicotine Analogues Molecular Conformation |
spellingShingle |
Science::Chemistry Nicotine Analogues Molecular Conformation Robertson, Patrick A. Villani, Luigi Martin, Danielle Robertson, Evan G. Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
description |
Nicotine has many physiological effects due to its neurotransmitter binding properties, associated with its usage as a recreational drug. Despite the great number of solution phase studies, very little has been published about gas phases spectroscopic properties. We report the first electronic spectra, obtained via two colour resonant two-photon ionisation spectroscopy. Evidence of two distinct conformers is supported by conformer specific IR-UV ion depletion spectra, interpreted with the aid of quantum chemistry calculations. Unconventional CH⋯N type hydrogen bonds between the rings play a key role in determining the conformational structures and giving rise to “blue-shift” perturbations in their IR spectra that facilitate their assignment. It is striking that the conformers are structurally very similar in the ground state, but upon excitation one of them undergoes a significant change in pyrrolidine puckering giving rise to an electronic spectrum of quite different character. |
author2 |
Asian Spectroscopy Conference 2020 |
author_facet |
Asian Spectroscopy Conference 2020 Robertson, Patrick A. Villani, Luigi Martin, Danielle Robertson, Evan G. |
format |
Conference or Workshop Item |
author |
Robertson, Patrick A. Villani, Luigi Martin, Danielle Robertson, Evan G. |
author_sort |
Robertson, Patrick A. |
title |
Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
title_short |
Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
title_full |
Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
title_fullStr |
Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
title_full_unstemmed |
Laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
title_sort |
laser spectroscopy of nicotine and related analogues : perturbations and puckering in pyridine and pyrrolidine rings |
publishDate |
2020 |
url |
https://hdl.handle.net/10356/144169 |
_version_ |
1683492949245034496 |