DNA-Pt complex interactions investigated by single-molecule force spectroscopy and surface-enhanced Raman spectroscopy

DNA-Pt complex interactions investigated by single-molecule force spectroscopy and surface-enhanced Raman spectroscopy

Biomacromolecules have dynamic three-dimensional structures that are selective for interacting with other biological components in cellular function. For example, DNA is the major target of anti-cancer drugs in chemotherapy medications. Despite the broad clinical successes in cancer treatment, Plati...

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Bibliographic Details
Main Authors: Dai, Xin, Li, Xiong, Leung, Cheuk Wai, Zhu, Hongni, Huang, Jinqing
Other Authors: Asian Spectroscopy Conference 2020
Format: Conference or Workshop Item
Language:English
Published: 2020
Subjects:
Science::Chemistry
DNA-small Molecule Interaction
Raman Spectroscopy
Online Access:https://hdl.handle.net/10356/144200
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Institution: Nanyang Technological University
Language: English
Description
Summary:Biomacromolecules have dynamic three-dimensional structures that are selective for interacting with other biological components in cellular function. For example, DNA is the major target of anti-cancer drugs in chemotherapy medications. Despite the broad clinical successes in cancer treatment, Platinum complexes exhibit severe side effects and acquired/intrinsic drug resistance due to off-target binding. Thus, an in-depth mechanistic understanding of DNA-Platinum complex interactions is required to support the rational design of new chemotherapy drugs that selectively bind to target DNA.

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