Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2

Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Photoexcitation of some microbial rhodopsins leads to ion transport across membranes. They contain all-trans-retinal as a chromophore, which is cova...

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Main Author: Mizutani, Yasuhisa
Other Authors: Asian Spectroscopy Conference 2020
Format: Conference or Workshop Item
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/144239
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1442392020-10-27T01:45:11Z Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2 Mizutani, Yasuhisa Asian Spectroscopy Conference 2020 Institute of Advanced Studies Science::Chemistry Time-resolved Resonance Raman Spectroscopy Light-driven Ion Pumps Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Photoexcitation of some microbial rhodopsins leads to ion transport across membranes. They contain all-trans-retinal as a chromophore, which is covalently bound to a lysine residue through a protonated Schiff base linkage and surrounded by seven transmembrane α helices. Absorption of a photon results in the chromophore isomerization and leads to a cyclic reaction. To reveal mechanism in ion pumping, it is essential to elucidate sequential changes in the chromophore structure in a photocycle. Resonance Raman spectroscopy enables us to examine the evolution of the structural changes of the retinal chromophore and the protein moiety.[1-7] Published version 2020-10-22T02:15:46Z 2020-10-22T02:15:46Z 2020 Conference Paper Mizutani, Y. (2020). Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2. Proc. Of the 7th Asian Spectroscopy Conference (ASC 2020). doi:10.32655/ASC_8-10_Dec2020.22 https://hdl.handle.net/10356/144239 10.32655/ASC_8-10_Dec2020.22 en © 2020 Nanyang Technological University. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Time-resolved Resonance Raman Spectroscopy
Light-driven Ion Pumps
spellingShingle Science::Chemistry
Time-resolved Resonance Raman Spectroscopy
Light-driven Ion Pumps
Mizutani, Yasuhisa
Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
description Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Photoexcitation of some microbial rhodopsins leads to ion transport across membranes. They contain all-trans-retinal as a chromophore, which is covalently bound to a lysine residue through a protonated Schiff base linkage and surrounded by seven transmembrane α helices. Absorption of a photon results in the chromophore isomerization and leads to a cyclic reaction. To reveal mechanism in ion pumping, it is essential to elucidate sequential changes in the chromophore structure in a photocycle. Resonance Raman spectroscopy enables us to examine the evolution of the structural changes of the retinal chromophore and the protein moiety.[1-7]
author2 Asian Spectroscopy Conference 2020
author_facet Asian Spectroscopy Conference 2020
Mizutani, Yasuhisa
format Conference or Workshop Item
author Mizutani, Yasuhisa
author_sort Mizutani, Yasuhisa
title Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
title_short Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
title_full Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
title_fullStr Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
title_full_unstemmed Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
title_sort unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein kr2
publishDate 2020
url https://hdl.handle.net/10356/144239
_version_ 1683494113255620608