Diazoalkane decay kinetics from UVA-active protein labelling molecules : trifluoromethyl phenyl diazirines

• Main Authors: Djordjevic, Ivan, Wicaksono, Gautama, Solic, Ivan, Steele, Terry W. J.
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry::Physical chemistry::Photochemistry; Diazirine; UVA
• Online Access: https://hdl.handle.net/10356/144265
• Institution: Nanyang Technological University

Trifluoromethyl phenyl diazirine (TPD) molecules are relatively stable carbene precursors, that readily form carbon covalent bonds with proteins. The stability of the diazoalkane intermediates is unknown, as are the factors which control carbene/diazoalkane ratios. This leads to incomplete carbene i...