The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting
Background: Cardiovascular disease is a leading cause of death in Singapore. It is therefore important to assess one’s risk of cardiovascular disease and evaluate what are the possible interventions that can be done to prevent the onset of cardiovascular disease. Beyond strategies such as weight los...
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sg-ntu-dr.10356-1444752020-11-08T20:11:07Z The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting Muhammad Nabil Bohari - Yang Yifan yifan.yang@nie.edu.sg Science::General Background: Cardiovascular disease is a leading cause of death in Singapore. It is therefore important to assess one’s risk of cardiovascular disease and evaluate what are the possible interventions that can be done to prevent the onset of cardiovascular disease. Beyond strategies such as weight loss for overweight individuals, it is also important to evaluate the quality and nutritional makeup of one’s diet. Purpose: Investigate a dose-response of leucine on cardiovascular disease risk indicators during intermittent fasting and determine a minimum amount of leucine necessary to illicit positive health benefits. Methods: 19 young overweight/obese male adults in a double-blinded, randomised control study design completed 4 weeks of an ADF programme, alternating between 3 meals/day on feeding days and 1 meal/day on fasting days.. Leucine doses of 0.02, 0.04, 0.06 or 0.08g/kg body mass per meal were randomly allocated to participants through food provision. Blood and lipid profiles were determined after blood draws at pre- and post-programme, with measurements collected throughout six laboratory sessions. Results: Significant main effects of time were observed on BM, SBP and LDL-C, suggesting effectiveness of ADF. There was also a significant interaction between time and leucine dose in SBP but further analysis determined that a dose- response relationship of leucine on SBP cannot be assumed. Conclusion: There is no dose- response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting. Future studies may look into implementing longer intervention periods. Bachelor of Science (Sport Science and Management) 2020-11-06T05:36:15Z 2020-11-06T05:36:15Z 2020 Final Year Project (FYP) https://hdl.handle.net/10356/144475 en application/pdf Nanyang Technological University |
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Science::General Muhammad Nabil Bohari The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
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Background: Cardiovascular disease is a leading cause of death in Singapore. It is therefore important to assess one’s risk of cardiovascular disease and evaluate what are the possible interventions that can be done to prevent the onset of cardiovascular disease. Beyond strategies such as weight loss for overweight individuals, it is also important to evaluate the quality and nutritional makeup of one’s diet. Purpose: Investigate a dose-response of leucine on cardiovascular disease risk indicators during intermittent fasting and determine a minimum amount of leucine necessary to illicit positive health benefits. Methods: 19 young overweight/obese male adults in a double-blinded, randomised control study design completed 4 weeks of an ADF programme, alternating between 3 meals/day on feeding days and 1 meal/day on fasting days.. Leucine doses of 0.02, 0.04, 0.06 or 0.08g/kg body mass per meal were randomly allocated to participants through food provision. Blood and lipid profiles were determined after blood draws at pre- and post-programme, with measurements collected throughout six laboratory sessions. Results: Significant main effects of time were observed on BM, SBP and LDL-C, suggesting effectiveness of ADF. There was also a significant interaction between time and leucine dose in SBP but further analysis determined that a dose- response relationship of leucine on SBP cannot be assumed. Conclusion: There is no dose- response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting. Future studies may look into implementing longer intervention periods. |
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- Muhammad Nabil Bohari |
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Final Year Project |
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Muhammad Nabil Bohari |
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Muhammad Nabil Bohari |
title |
The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
title_short |
The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
title_full |
The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
title_fullStr |
The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
title_full_unstemmed |
The dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
title_sort |
dose-response relationship of leucine on cardiovascular disease risk indicators in young male adults during intermittent fasting |
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Nanyang Technological University |
publishDate |
2020 |
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https://hdl.handle.net/10356/144475 |
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1688665355262623744 |