Apolipoprotein E4 polymorphism and outcomes from traumatic brain injury : a living systematic review and meta-analysis

• Main Authors: McFadyen, Charles A., Zeiler, Frederick A., Newcombe, Virginia, Synnot, Anneliese, Steyerberg, Ewout, Gruen, Russel Lindsay, Rosand, Jonathan, Palotie, Aarno, Maas, Andrew I. R., Menon, David K.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Genetics; Living Systematic Reviews
• Online Access: https://hdl.handle.net/10356/144650
• Institution: Nanyang Technological University

The mortality of traumatic brain injury (TBI) has been largely static despite advances in monitoring and imaging techniques. Substantial variance exists in outcome, not fully accounted for by baseline characteristics or injury severity, and genetic factors likely play a role in this variance. The ai...