Hepatic PPARα is critical in the metabolic adaptation to sepsis

• Main Authors: Paumelle, Réjane, Haas, Joel T., Hennuyer, Nathalie, Baugé, Eric, Deleye, Yann, Mesotten, Dieter, Langouche, Lies, Vanhoutte, Jonathan, Cudejko, Céline, Wouters, Kristiaan, Hannou, Sarah Anissa, Legry, Vanessa, Lancel, Steve, Lalloyer, Fanny, Polizzi, Arnaud, Smati, Sarra, Gourdy, Pierre, Vallez, Emmanuelle, Bouchaert, Emmanuel, Derudas, Bruno, Dehondt, Hélène, Gheeraert, Céline, Fleury, Sébastien, Tailleux, Anne, Montagner, Alexandra, Wahli, Walter, Van Den Berghe, Greet, Guillou, Hervé, Dombrowicz, David, Staels, Bart
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Nuclear Receptors; Sepsis
• Online Access: https://hdl.handle.net/10356/144807
• Institution: Nanyang Technological University

Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. We aimed to elucidate the previously unknown role of hepatic PPARα in the response to sepsis.