The necessity of d-Thr in the new antibiotic teixobactin : a molecular dynamics study

• Main Authors: Liu, Yang, Li, Weifeng, Chan-Park, Mary B., Mu, Yuguang
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Chirality; Lipids
• Online Access: https://hdl.handle.net/10356/144892
• Institution: Nanyang Technological University

Ever since the discovery of the new antibiotic teixobactin, studies of its structure–activity relationships have never ceased. Here we focus on the chirality of the threonine (Thr) residue, which belongs to the ring motif of teixobactin and plays an important role in the binding with its target, lip...