Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease

• Main Authors: Fougerat, Anne, Montagner, Alexandra, Loiseau, Nicolas, Guillou, Hervé, Wahli, Walter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Peroxisome Proliferator-activated Receptors; Synthetic Agonists
• Online Access: https://hdl.handle.net/10356/144925
• Institution: Nanyang Technological University

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease, which is characterized by lipid accumulation in hepatocytes, which can progress to non-alcoholic steatohepatitis (NASH)...