Synthesis of sialic acids, their derivatives, and analogs by using a whole‐cell catalyst

• Main Authors: Lv, Xun, Cao, Hongzhi, Lin, Baixue, Wang, Wei, Zhang, Wande, Duan, Qian, Tao, Yong, Liu, Xue-Wei, Li, Xuebing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Physics; Biosynthesis; E. Coli
• Online Access: https://hdl.handle.net/10356/144947
• Institution: Nanyang Technological University

Sialic acids (Sias) are important constituents of cell surface glycans. Ready access to Sias in large quantities would facilitate the development of carbohydrate‐based vaccines and small‐molecule drugs. We now present a facile method for synthesizing various natural forms and non‐natural derivatives...