Recent advances in reagent-controlled stereoselective/stereospecific glycosylation

• Main Authors: Yao, Hui, Vu, Minh Duy, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Glycosylation; Reagent-control
• Online Access: https://hdl.handle.net/10356/144949
• Institution: Nanyang Technological University

The formation of O-glycosidic linkage is arguably one of the most important topics in glycoscience due to the prevalence of O-glycosides in nature. Great efforts have been devoted to this field by many carbohydrate chemists to develop stereoselective/stereospecific glycosylation methodologies. Although glycosyl donor- and acceptor-controlled strategies have significantly progressed, the tedious design and pre-synthesis of substrates could not be avoided. On the other hand, reagent-controlled glycosylation can overcome these challenges and produce the desired selectivity by only altering external factors such as concentration, reagents or other reaction conditions. This mini-review discusses selected recent novel methodologies on reagent-mediated stereo-controlled glycosylation in the last decade, classified by the types of glycosyl donors.