Combination therapy using inhalable GapmeR and recombinant ACE2 for COVID-19

• Main Authors: Verma, Navin Kumar, Fazil, Mobashar Hussain Urf Turabe, Duggan, Shane P., Kelleher, Dermot
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; COVID-19 (2019-nCoV); GapmeR
• Online Access: https://hdl.handle.net/10356/145136
• Institution: Nanyang Technological University

Here we report our perspective on applying GapmeR technology in combination with recombinant angiotensin-converting enzyme 2 (ACE2) in the treatment of COVID-19 patients. GapmeR is a cell-permeating antisense single-stranded DNA molecule that can be designed to specifically target intracellular seve...