Nasopharyngeal cancer diagnosis with optical coherence tomography

• Main Authors: Ng, Beng Koon., Sirajudeen Gulam Razul.
• Other Authors: School of Electrical and Electronic Engineering
• Format: Research Report
• Language: English
• Published: 2008
• Subjects: DRNTU::Engineering::Electrical and electronic engineering::Control and instrumentation::Medical electronics
• Online Access: http://hdl.handle.net/10356/14524
• Institution: Nanyang Technological University

Two optical coherence tomography (OCT) systems were implemented in this work to extend the scope of an on-going research project, funded by the Singapore Cancer Syndicate to investigate the use of OCT for early nasopharyngeal cancer (NPC) diagnosis. The first OCT system is designed around a 1300 nm broadband superluminescence diode (SLD) source using the time-domain method. An axial resolution of 10 μm and an imaging depth of more than 2.5 mm were obtained with this system. An existing time-domain 800 nm OCT system based on a Ti:Sapphire laser source is modified into a Fourier-domain system using a nearinfrared (NIR) spectrometer. This eliminates the need for mechanical scanning on the reference arm of the OCT system and improves the imaging time by a factor of 3.7.