Estrogen exacerbates mammary involution through neutrophil-dependent and -independent mechanism

• Main Authors: Lim, Chew Leng, Or, Yu Zuan, Ong, Zoe, Chung, Hwa Hwa, Hayashi, Hirohito, Shrestha, Smeeta, Chiba, Shunsuke, Lin, Feng, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Pro-inflammatory; Microenvironment
• Online Access: https://hdl.handle.net/10356/145263
• Institution: Nanyang Technological University

There is strong evidence that the pro-inflammatory microenvironment during post-partum mammary involution promotes parity-associated breast cancer. Estrogen exposure during mammary involution drives tumor growth through neutrophils' activity. However, how estrogen and neutrophils influence mamm...