HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma

• Main Authors: Toh, Yi Long, Pang, Yi Yun, Shwe, Maung, Kanesvaran, Ravindran, Toh, Chee Keong, Chan, Alexandre, Ho, Han Kiat
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Pazopanib; Plasma Free Drug Concentration
• Online Access: https://hdl.handle.net/10356/145356
• Institution: Nanyang Technological University

Background: The selective occurrence of hepatotoxicity observed with use of pazopanib may be attributed to its high level of plasma protein binding and low hepatic extraction ratio. The primary objective was to investigate changes in free drug concentration amongst patients with varying albumin conc...