Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles

• Main Authors: Wang, Siyu, Guo, Xixi, Xiu, Weijun, Liu, Yang, Ren, Lili, Xiao, Huaxin, Yang, Fang, Gao, Yu, Xu, Chenjie, Wang, Lianhui
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Biochemistry; Controlled Drug Delivery
• Online Access: https://hdl.handle.net/10356/145395
• Institution: Nanyang Technological University

Conventional thrombolytic drugs for vascular blockage such as tissue plasminogen activator (tPA) are challenged by the low bioavailability, off-target side effects and limited penetration in thrombi, leading to delayed recanalization. We hypothesize that these challenges can be addressed with the ta...