Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

• Main Authors: Deng, Shaohui, Li, Xiaoxia, Liu, Shuang, Chen, Jifeng, Li, Mingqiang, Chew, Sing Yian, Leong, Kam W., Cheng, Du
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Cell Proliferation; Covalent Bonds
• Online Access: https://hdl.handle.net/10356/145406
• Institution: Nanyang Technological University

Controlled release of CRISPR-Cas9 ribonucleoprotein (RNP) and codelivery with other drugs remain a challenge. We demonstrate controlled release of CRISPR-Cas9 RNP and codelivery with antitumor photosensitizer chlorin e6 (Ce6) using near-infrared (NIR)– and reducing agent–responsive nanoparticles in...