MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy

• Main Authors: Zhao, Lingzhi, Li, Junyao, Su, Yaoquan, Yang, Liqiang, Chen, Liu, Qiang, Lei, Wang, Yajing, Xiang, Huijing, Tham, Phoebe Huijun, Peng, Juanjuan, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Medicine; Cell Death; Diseases
• Online Access: https://hdl.handle.net/10356/145423
• Institution: Nanyang Technological University

Although photodynamic therapy (PDT) has been clinically applied tumor hypoxia still greatly restricts the performance of this oxygen-dependent oncological treatment. The delivery of oxygen donors to tumor may produce excessive reactive oxygen species (ROS) and damage the peripheral tissues. Herein,...