MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy

• المؤلفون الرئيسيون: Zhao, Lingzhi, Li, Junyao, Su, Yaoquan, Yang, Liqiang, Chen, Liu, Qiang, Lei, Wang, Yajing, Xiang, Huijing, Tham, Phoebe Huijun, Peng, Juanjuan, Zhao, Yanli
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Medicine; Cell Death; Diseases
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/145423
• المؤسسة: Nanyang Technological University

Although photodynamic therapy (PDT) has been clinically applied tumor hypoxia still greatly restricts the performance of this oxygen-dependent oncological treatment. The delivery of oxygen donors to tumor may produce excessive reactive oxygen species (ROS) and damage the peripheral tissues. Herein,...