Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions

To explore the clinical uptake of pharmacogenetic/pharmacogenomic toxicity testing to reduce adverse drug reaction incidences, this paper analyzes data collected through semi-structured face-to-face interviews with clinicians and/or clinician-scientists, primarily in the context of cancer treatment...

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Main Author: Sun, Shirley
Other Authors: School of Social Sciences
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/145485
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1454852023-03-05T15:34:01Z Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions Sun, Shirley School of Social Sciences Social sciences::Sociology Genetic Testing Clinical Uptake To explore the clinical uptake of pharmacogenetic/pharmacogenomic toxicity testing to reduce adverse drug reaction incidences, this paper analyzes data collected through semi-structured face-to-face interviews with clinicians and/or clinician-scientists, primarily in the context of cancer treatment in multi-ethnic California (US), Vancouver (Canada) and Singapore. Recurrent themes in the data include the following: first, the scientific evidence for drug-gene interactions is perceived to be generally weak. Second, the primacy of medical treatment’s efficacy over toxicity is the predominant frame through which clinicians consider testing. Third, physicians tailor their decisions according to each patient’s tolerance levels for toxicity. Fourth, racially and ethnically based toxicity risk estimates are a factor shaping the clinical uptake of genetic tests, but they are controversial. These factors contribute to the low clinical uptake of toxicity testing for predictive purposes. We argue that the decision-makers’ framing and perception are additional features to be considered in Hedgecoe’s (2008) “clinical usefulness” framework. Ministry of Education (MOE) Accepted version This work was supported by the Singapore Ministry of Education under the AcRF Tier 1 Grant [grant number M4010724 RG59.10]. 2020-12-23T01:12:33Z 2020-12-23T01:12:33Z 2020 Journal Article Sun, S. (2020). Clinical usefulness of genetic testing for drug toxicity in cancer care: decision-makers’ framing, knowledge and perceptions, New Genetics and Society, 39(4), 359-384. doi:10.1080/14636778.2020.1730165 1463-6778 https://hdl.handle.net/10356/145485 10.1080/14636778.2020.1730165 2-s2.0-85080126687 4 39 359 384 en M4010724 RG59.10 New Genetics and Society This is an Accepted Manuscript of an article published by Informa UK Limited, trading as Taylor and Francis in New Genetics and Society on 27 Feb 2020, available online: http://www.tandfonline.com/10.1080/14636778.2020.1730165 application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Social sciences::Sociology
Genetic Testing
Clinical Uptake
spellingShingle Social sciences::Sociology
Genetic Testing
Clinical Uptake
Sun, Shirley
Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
description To explore the clinical uptake of pharmacogenetic/pharmacogenomic toxicity testing to reduce adverse drug reaction incidences, this paper analyzes data collected through semi-structured face-to-face interviews with clinicians and/or clinician-scientists, primarily in the context of cancer treatment in multi-ethnic California (US), Vancouver (Canada) and Singapore. Recurrent themes in the data include the following: first, the scientific evidence for drug-gene interactions is perceived to be generally weak. Second, the primacy of medical treatment’s efficacy over toxicity is the predominant frame through which clinicians consider testing. Third, physicians tailor their decisions according to each patient’s tolerance levels for toxicity. Fourth, racially and ethnically based toxicity risk estimates are a factor shaping the clinical uptake of genetic tests, but they are controversial. These factors contribute to the low clinical uptake of toxicity testing for predictive purposes. We argue that the decision-makers’ framing and perception are additional features to be considered in Hedgecoe’s (2008) “clinical usefulness” framework.
author2 School of Social Sciences
author_facet School of Social Sciences
Sun, Shirley
format Article
author Sun, Shirley
author_sort Sun, Shirley
title Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
title_short Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
title_full Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
title_fullStr Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
title_full_unstemmed Clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
title_sort clinical usefulness of genetic testing for drug toxicity in cancer care : decision-makers’ framing, knowledge and perceptions
publishDate 2020
url https://hdl.handle.net/10356/145485
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