Structure of the transmembrane domain of Salmonella insertion protein B (SipB). Mechanism of insertion investigated by novel biophysical and computational methodologies.

• Main Author: Torres, Jaume.
• Other Authors: School of Biological Sciences
• Format: Research Report
• Language: English
• Published: 2008
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/14554
• Institution: Nanyang Technological University

The entry of Salmonella into host cells begins with the translocation of bacterial effector proteins into host cells, SipB is involved in this translocon formation and is thus critical to invasion. Our main objective was to obtain a detailed picture of the mechanism of membrane insertion and possib...