Impaired nuclear export of the ribonucleoprotein complex and virus-induced cytotoxicity combine to restrict propagation of the A/Duck/Malaysia/02/2001 (H9N2) virus in human airway cells

• Main Authors: Kumar, Sriram, Yeo, Dawn, Muralidharan, Nisha Harur, Lai, Soak-Kuan, Tong, Cathlyn, Tan, Boon Huan, Sugrue, Richard J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Avian Influenza Virus; H9N2 Virus
• Online Access: https://hdl.handle.net/10356/145606
• Institution: Nanyang Technological University

In humans, (A549) cells impaired H9N2 virus nuclear export of the ribonucleoprotein (RNP) complex contrasted with the early and efficient nuclear export of the H1N1/WSN and pH1N1 virus RNP complexes. Although nuclear export of the RNP complex occurred via the nuclear pore complex, H9N2 virus infecti...