IRF-7 mediates type I IFN responses in endotoxin-challenged mice

• Main Authors: Sin, Wei-Xiang, Yeong, Joe Poh-Sheng, Lim, Thomas Jun Feng, Su, I-hsin, Connolly, John E., Chin, Keh-Chuang
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences; IRF-7; TLR4
• 在線閱讀: https://hdl.handle.net/10356/145633

IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is required for IFN-β production in the TLR4 pathway....