Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI....
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sg-ntu-dr.10356-1456612023-03-05T16:48:51Z Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study Beauchet, Olivier Montembeault, Maxime Allali, Gilles Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine MRI Aged Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI. Published version 2021-01-04T02:51:03Z 2021-01-04T02:51:03Z 2020 Journal Article Beauchet, O., Montembeault, M., & Allali, G. (2020). Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study. Frontiers in Aging Neuroscience, 11, 364-. doi:10.3389/fnagi.2019.00364 1663-4365 https://hdl.handle.net/10356/145661 10.3389/fnagi.2019.00364 32038223 11 en Frontiers in Aging Neuroscience © 2020 Beauchet, Montembeault and Allali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
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Science::Medicine MRI Aged Beauchet, Olivier Montembeault, Maxime Allali, Gilles Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
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Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI. |
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Lee Kong Chian School of Medicine (LKCMedicine) |
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Lee Kong Chian School of Medicine (LKCMedicine) Beauchet, Olivier Montembeault, Maxime Allali, Gilles |
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Article |
author |
Beauchet, Olivier Montembeault, Maxime Allali, Gilles |
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Beauchet, Olivier |
title |
Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
title_short |
Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
title_full |
Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
title_fullStr |
Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
title_full_unstemmed |
Brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
title_sort |
brain gray matter volume associations with abnormal gait imagery in patients with mild cognitive impairment : results of a cross-sectional study |
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2021 |
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https://hdl.handle.net/10356/145661 |
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1759853893193302016 |