Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bac...
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sg-ntu-dr.10356-1457212023-02-28T17:08:57Z Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria Bhattacharjya, Surajit Straus, Suzana K. School of Biological Sciences Science::Biological sciences Multi-drug Resistant Bacteria Extensively Drug Resistant Bacteria In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed. Ministry of Education (MOE) Published version S.B. acknowledges funding from Biomedical Research Council (BMRC), Singapore and Ministry of Education (MOE), Singapore. S.K.S. thanks the Natural Sciences and Engineering Research Council of Canada for funding. 2021-01-06T02:13:32Z 2021-01-06T02:13:32Z 2020 Journal Article Bhattacharjya, S., & Straus, S. K. (2020). Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria. International Journal of Molecular Sciences, 21(16), 5773-. doi:10.3390/ijms21165773 1661-6596 https://hdl.handle.net/10356/145721 10.3390/ijms21165773 32796755 16 21 en International Journal of Molecular Sciences © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
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Science::Biological sciences Multi-drug Resistant Bacteria Extensively Drug Resistant Bacteria Bhattacharjya, Surajit Straus, Suzana K. Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
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In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed. |
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School of Biological Sciences |
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School of Biological Sciences Bhattacharjya, Surajit Straus, Suzana K. |
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Article |
author |
Bhattacharjya, Surajit Straus, Suzana K. |
author_sort |
Bhattacharjya, Surajit |
title |
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
title_short |
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
title_full |
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
title_fullStr |
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
title_full_unstemmed |
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
title_sort |
design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria |
publishDate |
2021 |
url |
https://hdl.handle.net/10356/145721 |
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1759854704688365568 |