Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria

In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bac...

Full description

Saved in:
Bibliographic Details
Main Authors: Bhattacharjya, Surajit, Straus, Suzana K.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Online Access:https://hdl.handle.net/10356/145721
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-145721
record_format dspace
spelling sg-ntu-dr.10356-1457212023-02-28T17:08:57Z Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria Bhattacharjya, Surajit Straus, Suzana K. School of Biological Sciences Science::Biological sciences Multi-drug Resistant Bacteria Extensively Drug Resistant Bacteria In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed. Ministry of Education (MOE) Published version S.B. acknowledges funding from Biomedical Research Council (BMRC), Singapore and Ministry of Education (MOE), Singapore. S.K.S. thanks the Natural Sciences and Engineering Research Council of Canada for funding. 2021-01-06T02:13:32Z 2021-01-06T02:13:32Z 2020 Journal Article Bhattacharjya, S., & Straus, S. K. (2020). Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria. International Journal of Molecular Sciences, 21(16), 5773-. doi:10.3390/ijms21165773 1661-6596 https://hdl.handle.net/10356/145721 10.3390/ijms21165773 32796755 16 21 en International Journal of Molecular Sciences © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences
Multi-drug Resistant Bacteria
Extensively Drug Resistant Bacteria
spellingShingle Science::Biological sciences
Multi-drug Resistant Bacteria
Extensively Drug Resistant Bacteria
Bhattacharjya, Surajit
Straus, Suzana K.
Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
description In an era where the pipeline of new antibiotic development is drying up, the continuous rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine threats to human health. Although antimicrobial peptides (AMPs) may serve as promising leads against drug resistant bacteria, only a few AMPs are in advanced clinical trials. The limitations of AMPs, namely their low in vivo activity, toxicity, and poor bioavailability, need to be addressed. Here, we review engineering of frog derived short α-helical AMPs (aurein, temporins) and lipopolysaccharide (LPS) binding designed β-boomerang AMPs for further development. The discovery of novel cell selective AMPs from the human proprotein convertase furin is also discussed.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Bhattacharjya, Surajit
Straus, Suzana K.
format Article
author Bhattacharjya, Surajit
Straus, Suzana K.
author_sort Bhattacharjya, Surajit
title Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
title_short Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
title_full Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
title_fullStr Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
title_full_unstemmed Design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
title_sort design, engineering and discovery of novel α-helical and β-boomerang antimicrobial peptides against drug resistant bacteria
publishDate 2021
url https://hdl.handle.net/10356/145721
_version_ 1759854704688365568