Increased protein S-glutathionylation in Leber’s hereditary optic neuropathy (LHON)

• المؤلفون الرئيسيون: Zhou, Lei, Chan, James Chun Yip, Chupin, Stephanie, Gueguen, Naïg, Desquiret-Dumas, Valérie, Koh, Siew Kwan, Li, Jianguo, Gao, Yan, Deng, Lu, Verma, Chandra Shekhar, Beuerman, Roger W., Chan, Eric Chun Yong, Milea, Dan, Reynier, Pascal
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences; Leber’s Hereditary Optic Neuropathy; LHON
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/145724
• المؤسسة: Nanyang Technological University

Leber’s hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA-related diseases. The pathogenicity of mutations in genes encoding components of mitochondrial Complex I is well established, but the underlying pathomechanisms of the...