Bioresorbable polymeric scaffold in cardiovascular applications
Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that...
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sg-ntu-dr.10356-1457272023-07-14T16:02:03Z Bioresorbable polymeric scaffold in cardiovascular applications Toong, Daniel Wee Yee Toh, Han Wei Ng, Jaryl Chen Koon Wong, Philip En Hou Leo, Hwa Liang Venkatraman, Subramanian Tan, Lay Poh Ang, Hui Ying Huang, Yingying School of Materials Science and Engineering Science::Biological sciences Bioresorbable Scaffolds Biomaterials Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6–8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript. Published version 2021-01-06T03:10:35Z 2021-01-06T03:10:35Z 2020 Journal Article Toong, D. W. Y., Toh, H. W., Ng, J. C. K., Wong, P. E. H., Leo, H. L., Venkatraman, S., . . . Huang, Y. (2020). Bioresorbable polymeric scaffold in cardiovascular applications. International Journal of Molecular Sciences, 21(10), 3444-. doi:10.3390/ijms21103444 1661-6596 https://hdl.handle.net/10356/145727 10.3390/ijms21103444 32414114 10 21 en International Journal of Molecular Sciences © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
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Science::Biological sciences Bioresorbable Scaffolds Biomaterials Toong, Daniel Wee Yee Toh, Han Wei Ng, Jaryl Chen Koon Wong, Philip En Hou Leo, Hwa Liang Venkatraman, Subramanian Tan, Lay Poh Ang, Hui Ying Huang, Yingying Bioresorbable polymeric scaffold in cardiovascular applications |
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Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6–8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript. |
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School of Materials Science and Engineering |
author_facet |
School of Materials Science and Engineering Toong, Daniel Wee Yee Toh, Han Wei Ng, Jaryl Chen Koon Wong, Philip En Hou Leo, Hwa Liang Venkatraman, Subramanian Tan, Lay Poh Ang, Hui Ying Huang, Yingying |
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Article |
author |
Toong, Daniel Wee Yee Toh, Han Wei Ng, Jaryl Chen Koon Wong, Philip En Hou Leo, Hwa Liang Venkatraman, Subramanian Tan, Lay Poh Ang, Hui Ying Huang, Yingying |
author_sort |
Toong, Daniel Wee Yee |
title |
Bioresorbable polymeric scaffold in cardiovascular applications |
title_short |
Bioresorbable polymeric scaffold in cardiovascular applications |
title_full |
Bioresorbable polymeric scaffold in cardiovascular applications |
title_fullStr |
Bioresorbable polymeric scaffold in cardiovascular applications |
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Bioresorbable polymeric scaffold in cardiovascular applications |
title_sort |
bioresorbable polymeric scaffold in cardiovascular applications |
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2021 |
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https://hdl.handle.net/10356/145727 |
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1773551295337070592 |