Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6

Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and faci...

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Main Authors: Khan, Munezza Ata, Mohammad Mujahid
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/145833
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1458332023-07-14T16:02:22Z Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6 Khan, Munezza Ata Mohammad Mujahid School of Materials Science and Engineering Engineering::Materials Interleukin 6 Biosensor Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications. Published version 2021-01-11T07:08:53Z 2021-01-11T07:08:53Z 2020 Journal Article Khan, M. A., & Mohammad Mujahid. (2020). Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6. Sensors, 20(3), 646-. doi:10.3390/s20030646 1424-8220 https://hdl.handle.net/10356/145833 10.3390/s20030646 31979357 3 20 en Sensors © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials
Interleukin 6
Biosensor
spellingShingle Engineering::Materials
Interleukin 6
Biosensor
Khan, Munezza Ata
Mohammad Mujahid
Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
description Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Khan, Munezza Ata
Mohammad Mujahid
format Article
author Khan, Munezza Ata
Mohammad Mujahid
author_sort Khan, Munezza Ata
title Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
title_short Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
title_full Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
title_fullStr Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
title_full_unstemmed Recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
title_sort recent advances in electrochemical and optical biosensors designed for detection of interleukin 6
publishDate 2021
url https://hdl.handle.net/10356/145833
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