Microenvironmental hypoxia induces dynamic changes in lung cancer synthesis and secretion of extracellular vesicles

• Main Authors: Tse, Shun Wilford, Tan, Chee Fan, Park, Jung Eun, Gnanasekaran, JebaMercy, Gupta, Nikhil, Low, Jee Keem, Yeoh, Kheng Wei, Chng, Wee Joo, Tay, Chor Yong, McCarthy, Neil E., Lim, Sai Kiang, Sze, Siu Kwan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Extracellular Vesicles; Hypoxia
• Online Access: https://hdl.handle.net/10356/145954
• Institution: Nanyang Technological University

Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that hypoxic tumours synthesize hypoxia-sensitive proteins for...