The bactericidal fatty acid mimetic 2CCA-1 selectively targets pneumococcal extracellular polyunsaturated fatty acid metabolism

• Main Authors: Reithuber, Elisabeth, Nannapaneni, Priyanka, Rzhepishevska, Olena, Lindgren, Anders E. G., Ilchenko, Oleksandr, Normark, Staffan, Almqvist, Fredrik, Henriques-Normark, Birgitta, Mellroth, Peter
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Streptococcus Pneumoniae; Pneumococci
• Online Access: https://hdl.handle.net/10356/146001
• Institution: Nanyang Technological University

Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum anti...