Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients

• Main Authors: Rathore, Abhay P. S., Senanayake, Manouri, Athapathu, Arjuna Salinda, Gunasena, Sunethra, Karunaratna, Irantha, Leong, Wei Yee, Lim, Ting, Mantri, Chinmay Kumar, Wilder-Smith, Annelies, St. John, Ashley L.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Biomarkers; Dengue Virus
• Online Access: https://hdl.handle.net/10356/146070
• Institution: Nanyang Technological University

Dengue induces a spectrum of severity in humans from the milder dengue fever to severe disease, or dengue hemorrhagic fever (DHF). Chymase is a candidate biomarker that may aid dengue prognosis. This prospective study aimed to identify whether warning signs of severe dengue, including hypovolemia an...