Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)

The introduction of femtosecond laser-assisted cataract surgery is an alternative approach to conventional cataract surgery. Our study aimed to determine the effectiveness of femtosecond laser-assisted capsulotomy in the presence of different ophthalmic viscoelastic devices (OVDs) in the anterior ch...

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Main Authors: Mansoor, Hassan, Liu, Yu-Chi, Wong, Yoke Rung, Lwin, Nyein C., Seah, Xin Y., Mehta, Jodhbir Singh
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/146130
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spelling sg-ntu-dr.10356-1461302023-07-14T16:00:41Z Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs) Mansoor, Hassan Liu, Yu-Chi Wong, Yoke Rung Lwin, Nyein C. Seah, Xin Y. Mehta, Jodhbir Singh School of Materials Science and Engineering Engineering::Materials Surgery Translational Research The introduction of femtosecond laser-assisted cataract surgery is an alternative approach to conventional cataract surgery. Our study aimed to determine the effectiveness of femtosecond laser-assisted capsulotomy in the presence of different ophthalmic viscoelastic devices (OVDs) in the anterior chamber. Fresh porcine eyes (n = 96) underwent LDV Z8-assisted anterior capsulotomy, either in the presence of an OVD (Viscoat, Provisc, Healon, Healon GV or HPMC) or without, using 90% and 150% energies respectively. Following that, the capsule circularity, tag's arc-length, tag-length, tag-area and rupture strength (mN) of the residual capsular bag were evaluated. We found that increasing energy from 90 to 150% across the OVD sub-groups improved the studied capsulotomy parameters. Amongst the 90% energy sub-groups, the circularity and tag-parameters were worse with Viscoat and Healon GV, which have higher refractive index and viscosity compared to the aqueous humour. Using 150% energy, Healon GV showed a significantly worse total arc-length (p = 0.01), total tag-length (p = 0.03) and total tag-area (p = 0.05) compared to the control group. We concluded that; an OVD with a refractive index similar to aqueous humour and lower viscosity, such as Healon or Provisc, as well as a higher energy setting, are recommended, to enhance the efficacy of laser capsulotomy. National Medical Research Council (NMRC) National Research Foundation (NRF) Published version This research was supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) programme (NMRC/TCR/1021-SERI/2013), and by Duke-NUS Medical School, Singapore under its Academia Clinical Programme (ACP) (R1396/82/2016). 2021-01-27T05:18:03Z 2021-01-27T05:18:03Z 2020 Journal Article Mansoor, H., Liu, Y.-C., Wong, Y. R., Lwin, N. C., Seah, X. Y., & Mehta, J. S. (2020). Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs). Scientific Reports, 10(1), 21542-. doi:10.1038/s41598-020-78361-8 2045-2322 https://hdl.handle.net/10356/146130 10.1038/s41598-020-78361-8 33298985 2-s2.0-85097391003 1 10 en Scientific reports © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials
Surgery
Translational Research
spellingShingle Engineering::Materials
Surgery
Translational Research
Mansoor, Hassan
Liu, Yu-Chi
Wong, Yoke Rung
Lwin, Nyein C.
Seah, Xin Y.
Mehta, Jodhbir Singh
Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
description The introduction of femtosecond laser-assisted cataract surgery is an alternative approach to conventional cataract surgery. Our study aimed to determine the effectiveness of femtosecond laser-assisted capsulotomy in the presence of different ophthalmic viscoelastic devices (OVDs) in the anterior chamber. Fresh porcine eyes (n = 96) underwent LDV Z8-assisted anterior capsulotomy, either in the presence of an OVD (Viscoat, Provisc, Healon, Healon GV or HPMC) or without, using 90% and 150% energies respectively. Following that, the capsule circularity, tag's arc-length, tag-length, tag-area and rupture strength (mN) of the residual capsular bag were evaluated. We found that increasing energy from 90 to 150% across the OVD sub-groups improved the studied capsulotomy parameters. Amongst the 90% energy sub-groups, the circularity and tag-parameters were worse with Viscoat and Healon GV, which have higher refractive index and viscosity compared to the aqueous humour. Using 150% energy, Healon GV showed a significantly worse total arc-length (p = 0.01), total tag-length (p = 0.03) and total tag-area (p = 0.05) compared to the control group. We concluded that; an OVD with a refractive index similar to aqueous humour and lower viscosity, such as Healon or Provisc, as well as a higher energy setting, are recommended, to enhance the efficacy of laser capsulotomy.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Mansoor, Hassan
Liu, Yu-Chi
Wong, Yoke Rung
Lwin, Nyein C.
Seah, Xin Y.
Mehta, Jodhbir Singh
format Article
author Mansoor, Hassan
Liu, Yu-Chi
Wong, Yoke Rung
Lwin, Nyein C.
Seah, Xin Y.
Mehta, Jodhbir Singh
author_sort Mansoor, Hassan
title Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
title_short Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
title_full Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
title_fullStr Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
title_full_unstemmed Evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (OVDs)
title_sort evaluation of femtosecond laser-assisted anterior capsulotomy in the presence of ophthalmic viscoelastic devices (ovds)
publishDate 2021
url https://hdl.handle.net/10356/146130
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