One year structural and functional glaucoma progression after trabeculectomy

We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visit...

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Main Authors: Chua, Jacqueline, Kadziauskienė, Aistė, Wong, Damon Wing Kee, Ašoklis, Rimvydas, Lesinskas, Eugenijus, Quang, Nguyen Duc, Chong, Rachel, Tan, Bingyao, Girard, Michaël J. A., Mari, Jean Martial, Crowston, Jonathan G., Aung, Tin, Schmetterer, Leopold
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/146176
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spelling sg-ntu-dr.10356-1461762023-03-05T16:44:25Z One year structural and functional glaucoma progression after trabeculectomy Chua, Jacqueline Kadziauskienė, Aistė Wong, Damon Wing Kee Ašoklis, Rimvydas Lesinskas, Eugenijus Quang, Nguyen Duc Chong, Rachel Tan, Bingyao Girard, Michaël J. A. Mari, Jean Martial Crowston, Jonathan G. Aung, Tin Schmetterer, Leopold Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Diagnostic Markers Optic Nerve Diseases We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visits over one year. Linear mixed models were used to investigate factors associated with VF and RNFL. VF improved during the first 3 months of follow-up (2.55 ± 1.06 dB/year) and worsened at later visits (−1.14 ± 0.29 dB/year). RNFL thickness reduced by −4.21 ± 0.25 µm/year from 1st month of follow-up. Eyes with an absence of initial VF improvement (β = 0.64; 0.30–0.98), RNFL thinning (β = 0.15; 0.08–0.23), increasing intraocular pressure (IOP; β = −0.11; −0.18 to −0.03) and severe glaucoma (β = −10.82; −13.61 to −8.02) were associated with VF deterioration. Eyes with VF deterioration (β = 0.19; 0.08–0.29), increasing IOP (β = −0.09; −0.17 to −0.01), and moderate (β = −6.33; −12.17 to −0.49) or severe glaucoma (β = −19.58; −24.63 to −14.52) were associated with RNFL thinning. Changes in RNFL structure and function occur over a 1-year follow-up period after trabeculectomy. Early VF improvement is more likely to occur in patients with mild/moderate glaucoma, whereas those with severe glaucoma show greater decline over one year. Our findings indicate that progression is observable using OCT, even in late-stage glaucoma. National Medical Research Council (NMRC) Published version The study is funded by National Medical Research Council (NMRC CG/C010A/2017 and OFIRG/0048/2017 and TA/MOH-000249-00/2018) and the Duke-NUS Medical School (Duke-NUS-KP(Coll)/2018/0009A), Singapore. The sponsor or funding organization had no role in the design or conduct of this research. 2021-01-29T03:32:47Z 2021-01-29T03:32:47Z 2020 Journal Article Chua, J., Kadziauskienė, A., Wong, D. W. K., Ašoklis, R., Lesinskas, E., Quang, N. D., . . . Schmetterer, L. (2020). One year structural and functional glaucoma progression after trabeculectomy. Scientific Reports, 10(1), 2808-. doi:10.1038/s41598-020-59792-9 2045-2322 0000-0002-6474-5293 0000-0002-1169-6547 https://hdl.handle.net/10356/146176 10.1038/s41598-020-59792-9 32071369 2-s2.0-85079703711 1 10 en NMRC CG/C010A/2017 OFIRG/0048/2017 TA/MOH-000249-00/201 Scientific Reports © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
Diagnostic Markers
Optic Nerve Diseases
spellingShingle Science::Medicine
Diagnostic Markers
Optic Nerve Diseases
Chua, Jacqueline
Kadziauskienė, Aistė
Wong, Damon Wing Kee
Ašoklis, Rimvydas
Lesinskas, Eugenijus
Quang, Nguyen Duc
Chong, Rachel
Tan, Bingyao
Girard, Michaël J. A.
Mari, Jean Martial
Crowston, Jonathan G.
Aung, Tin
Schmetterer, Leopold
One year structural and functional glaucoma progression after trabeculectomy
description We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visits over one year. Linear mixed models were used to investigate factors associated with VF and RNFL. VF improved during the first 3 months of follow-up (2.55 ± 1.06 dB/year) and worsened at later visits (−1.14 ± 0.29 dB/year). RNFL thickness reduced by −4.21 ± 0.25 µm/year from 1st month of follow-up. Eyes with an absence of initial VF improvement (β = 0.64; 0.30–0.98), RNFL thinning (β = 0.15; 0.08–0.23), increasing intraocular pressure (IOP; β = −0.11; −0.18 to −0.03) and severe glaucoma (β = −10.82; −13.61 to −8.02) were associated with VF deterioration. Eyes with VF deterioration (β = 0.19; 0.08–0.29), increasing IOP (β = −0.09; −0.17 to −0.01), and moderate (β = −6.33; −12.17 to −0.49) or severe glaucoma (β = −19.58; −24.63 to −14.52) were associated with RNFL thinning. Changes in RNFL structure and function occur over a 1-year follow-up period after trabeculectomy. Early VF improvement is more likely to occur in patients with mild/moderate glaucoma, whereas those with severe glaucoma show greater decline over one year. Our findings indicate that progression is observable using OCT, even in late-stage glaucoma.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Chua, Jacqueline
Kadziauskienė, Aistė
Wong, Damon Wing Kee
Ašoklis, Rimvydas
Lesinskas, Eugenijus
Quang, Nguyen Duc
Chong, Rachel
Tan, Bingyao
Girard, Michaël J. A.
Mari, Jean Martial
Crowston, Jonathan G.
Aung, Tin
Schmetterer, Leopold
format Article
author Chua, Jacqueline
Kadziauskienė, Aistė
Wong, Damon Wing Kee
Ašoklis, Rimvydas
Lesinskas, Eugenijus
Quang, Nguyen Duc
Chong, Rachel
Tan, Bingyao
Girard, Michaël J. A.
Mari, Jean Martial
Crowston, Jonathan G.
Aung, Tin
Schmetterer, Leopold
author_sort Chua, Jacqueline
title One year structural and functional glaucoma progression after trabeculectomy
title_short One year structural and functional glaucoma progression after trabeculectomy
title_full One year structural and functional glaucoma progression after trabeculectomy
title_fullStr One year structural and functional glaucoma progression after trabeculectomy
title_full_unstemmed One year structural and functional glaucoma progression after trabeculectomy
title_sort one year structural and functional glaucoma progression after trabeculectomy
publishDate 2021
url https://hdl.handle.net/10356/146176
_version_ 1759856382924816384