The neutrally charged diarylurea compound PQ401 kills antibiotic-resistant and antibiotic-tolerant Staphylococcus aureus

• Main Authors: Kim, Wooseong, Zou, Guijin, Pan, Wen, Fricke, Nico, Faizi, Hammad A., Kim, Soo Min, Khader, Rajamohammed, Li, Silei, Lee, Kiho, Escorba, Iliana, Vlahovska, Petia M., Gao, Huajian, Ausubel, Frederick M., Mylonakis, Eleftherios
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Mechanical engineering; Persisters; Antibiotic Tolerance
• Online Access: https://hdl.handle.net/10356/146178
• Institution: Nanyang Technological University

Resistance or tolerance to traditional antibiotics is a challenging issue in antimicrobial chemotherapy. Moreover, traditional bactericidal antibiotics kill only actively growing bacterial cells, whereas nongrowing metabolically inactive cells are tolerant to and therefore "persist" in the...