Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis

• Main Authors: Tay, Vanessa Shi Yun, Devaraj, Surabhi, Koh, Tracy, Ke, Guo, Crasta, Karen Carmelina, Yusuf Ali
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Cell Death; Senescence
• Online Access: https://hdl.handle.net/10356/146226
• Institution: Nanyang Technological University

DNA damage and DNA damage response (DDR) pathways in β-cells have received little attention especially in the context of type-2 diabetes. We postulate that p21 plays a key role in DDR by preventing apoptosis, associated through its overexpression triggered by DNA stand breaks (DSBs). Our results sho...