Emergence of spatio-temporal variations in chemotherapeutic drug efficacy : in-vitro and in-silico 3D tumour spheroid studies

• Main Authors: Sheraton, Muniraj Vivek, Chiew, Geraldine Giap Ying, Melnikov, Valentin, Tan, E. Y., Luo, K. Q., Verma, N., Sloot, Peter M. A.
• Other Authors: Interdisciplinary Graduate School (IGS)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Reaction-diffusion Model; Pharmacokinetics
• Online Access: https://hdl.handle.net/10356/146307
• Institution: Nanyang Technological University

Background: The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from...