Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection

Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection

Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon...

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Bibliographic Details
Main Authors: Wiraja, Christian, Mathiyazhakan, Malathi, Movahedi, Fatemeh, Upputuri, Paul Kumar, Cheng, Yingying, Pramanik, Manojit, Yang, Liang, Becker, David Laurence, Xu, Chenjie
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2021
Subjects:
Engineering::Bioengineering
Gold Nanostars
NIR-responsive Liposome
Online Access:https://hdl.handle.net/10356/146483
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Institution: Nanyang Technological University
Language: English
Description
Summary:Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.

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