The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization

• Main Authors: Okamoto, Sayuri, Naito, Tomoki, Shigetomi, Ryo, Kosugi, Yusuke, Nakayama, Kazuhisa, Takatsu, Hiroyuki, Shin, Hye-Won
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; ATPase 10A; ATPase 10D
• Online Access: https://hdl.handle.net/10356/146642
• Institution: Nanyang Technological University

Mammalian P4-ATPases specifically localize to the plasma membrane and the membranes of intracellular compartments. P4-ATPases contain 10 transmembrane domains, and their N- and C-terminal (NT and CT) regions face the cytoplasm. Among the ATP10 and ATP11 proteins of P4-ATPases, ATP10A, ATP10D, ATP11A...