Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4

• Main Authors: Kolb, Ryan, Kluz, Paige, Tan, Zhen Wei, Borcherding, Nicholas, Bormann, Nicholas, Vishwakarma, Ajaykumar, Balcziak, Louis, Zhu, Pengcheng, Davies, Brandon S. J., Gourronc, Francoise, Liu, Ling-Zhi, Ge, Xin, Jiang, Bing-Hua, Gibson-Corley, Katherine, Klingelhutz, Aloysius, Tan, Nguan Soon, Zhu, Yuwen, Sutterwala, Fayyaz S., Shen, Xian, Zhang, Weizhou
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Breast Cancer; Inflammation
• Online Access: https://hdl.handle.net/10356/146661
• Institution: Nanyang Technological University

Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose limiting toxicities and obesity-related complications, highlighting the need to...