Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state

• Main Authors: Bu, Wenting, Levitskaya, Zarina, Loh, Zhi Yang, Jin, Shengyang, Basu, Shibom, Ero, Rya, Yan, Xinfu, Wang, Meitian, Ngan, So Fong Cam, Sze, Siu Kwan, Tan, Suet-Mien, Gao, Yong-Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Kindlin; FERM
• Online Access: https://hdl.handle.net/10356/146721
• Institution: Nanyang Technological University

Kindlin-1, -2, and -3, directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their functional significance and link to several diseases, structural information on full-length kindlin proteins remains unknown. Here, we report the crystal structure of human...