Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody

• Main Authors: Wirawan, Melissa, Fibriansah, Guntur, Marzinek, Jan K., Lim, Xin Xiang, Ng, Thiam-Seng, Sim, Adelene Y. L., Zhang, Qian, Kostyuchenko, Victor A., Shi, Jian, Smith, Scott A., Verma, Chandra Shekhar, Anand, Ganesh, Crowe, James E., Bond, Peter J., Lok, Shee-Mei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Cryo-EM; Dengue Virus
• Online Access: https://hdl.handle.net/10356/146757
• Institution: Nanyang Technological University

Dengue virus (DENV) particles are released from cells in different maturation states. Fully immature DENV (immDENV) is generally non-infectious, but can become infectious when complexed with anti-precursor membrane (prM) protein antibodies. It is unknown how anti-prM antibody-coated particles can un...