Transformation of nanomaterials and its implications in gut nanotoxicology

Ingestion of engineered nanomaterials (ENMs) is inevitable due to their widespread utilization in the agrifood industry. Safety evaluation has become pivotal to identify the consequences on human health of exposure to these ingested ENMs. Much of the current understanding of nanotoxicology in the ga...

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Main Authors: Setyawati, Magdiel Inggrid, Zhao, Zhitong, Ng, Kee Woei
Other Authors: School of Materials Science and Engineering
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/146770
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1467702023-07-14T16:03:53Z Transformation of nanomaterials and its implications in gut nanotoxicology Setyawati, Magdiel Inggrid Zhao, Zhitong Ng, Kee Woei School of Materials Science and Engineering Nanyang Environment and Water Research Institute Engineering::Materials::Nanostructured materials Engineering::Nanotechnology Agrifood Products Engineered Nanomaterials Ingestion of engineered nanomaterials (ENMs) is inevitable due to their widespread utilization in the agrifood industry. Safety evaluation has become pivotal to identify the consequences on human health of exposure to these ingested ENMs. Much of the current understanding of nanotoxicology in the gastrointestinal tract (GIT) is derived from studies utilizing pristine ENMs. In reality, agrifood ENMs interact with their microenvironment, and undergo multiple physicochemical transformations, such as aggregation/agglomeration, dissolution, speciation change, and surface characteristics alteration, across their life cycle from synthesis to consumption. This work sieves out the implications of ENM transformations on their behavior, stability, and reactivity in food and product matrices and through the GIT, in relation to measured toxicological profiles. In particular, a strong emphasis is given to understand the mechanisms through which these transformations can affect ENM induced gut nanotoxicity. Nanyang Technological University Accepted version Nanyang Technological University—Harvard School of Public Health Initiative for Sustainable Nanotechnology (NTU‐Harvard SusNano). 2021-03-10T05:27:45Z 2021-03-10T05:27:45Z 2020 Journal Article Setyawati, M. I., Zhao, Z., & Ng, K. W. (2020). Transformation of nanomaterials and its implications in gut nanotoxicology. Small, 16(36), 2001246-. doi:10.1002/smll.202001246 1613-6810 https://hdl.handle.net/10356/146770 10.1002/smll.202001246 36 16 2001246 en Small This is the peer reviewed version of the following article: Setyawati, M. I., Zhao, Z., & Ng, K. W. (2020). Transformation of nanomaterials and its implications in gut nanotoxicology. Small, 16(36), 2001246-. doi:10.1002/smll.202001246, which has been published in final form at https://doi.org/10.1002/smll.202001246. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials::Nanostructured materials
Engineering::Nanotechnology
Agrifood Products
Engineered Nanomaterials
spellingShingle Engineering::Materials::Nanostructured materials
Engineering::Nanotechnology
Agrifood Products
Engineered Nanomaterials
Setyawati, Magdiel Inggrid
Zhao, Zhitong
Ng, Kee Woei
Transformation of nanomaterials and its implications in gut nanotoxicology
description Ingestion of engineered nanomaterials (ENMs) is inevitable due to their widespread utilization in the agrifood industry. Safety evaluation has become pivotal to identify the consequences on human health of exposure to these ingested ENMs. Much of the current understanding of nanotoxicology in the gastrointestinal tract (GIT) is derived from studies utilizing pristine ENMs. In reality, agrifood ENMs interact with their microenvironment, and undergo multiple physicochemical transformations, such as aggregation/agglomeration, dissolution, speciation change, and surface characteristics alteration, across their life cycle from synthesis to consumption. This work sieves out the implications of ENM transformations on their behavior, stability, and reactivity in food and product matrices and through the GIT, in relation to measured toxicological profiles. In particular, a strong emphasis is given to understand the mechanisms through which these transformations can affect ENM induced gut nanotoxicity.
author2 School of Materials Science and Engineering
author_facet School of Materials Science and Engineering
Setyawati, Magdiel Inggrid
Zhao, Zhitong
Ng, Kee Woei
format Article
author Setyawati, Magdiel Inggrid
Zhao, Zhitong
Ng, Kee Woei
author_sort Setyawati, Magdiel Inggrid
title Transformation of nanomaterials and its implications in gut nanotoxicology
title_short Transformation of nanomaterials and its implications in gut nanotoxicology
title_full Transformation of nanomaterials and its implications in gut nanotoxicology
title_fullStr Transformation of nanomaterials and its implications in gut nanotoxicology
title_full_unstemmed Transformation of nanomaterials and its implications in gut nanotoxicology
title_sort transformation of nanomaterials and its implications in gut nanotoxicology
publishDate 2021
url https://hdl.handle.net/10356/146770
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