The polybasic insert, the RBD of the SARS-CoV-2 spike protein, and the feline coronavirus - evolved or yet to evolve

• Main Authors: Budhraja, Anshul, Pandey, Sakshi, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Venkatraman, Prasanna
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Spike Protein; Furin
• Online Access: https://hdl.handle.net/10356/146866
• Institution: Nanyang Technological University

Recent research on the SARS-CoV-2 pandemic has exploded around the furin-cleavable polybasic insert PRRAR↓S, found within the spike protein. The insert and the receptor-binding domain, (RBD), are vital clues in the Sherlock Holmes-like investigation into the origin of the virus and in its zoonotic c...