Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice

• Main Authors: Vanan, Sarivin, Zeng, Xiaoxia, Chia, Sook Yoong, Varnäs, Katarina, Jiang, Mei, Zhang, Ke, Saw, Wuan Ting, Padmanabhan, Parasuraman, Yu, Wei-Ping, Zhou, Zhi-Dong, Halldin, Christer, Gulyás, Balázs, Tan, Eng-King, Zeng, Li
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Parkinson’s Disease; VPS35 D620
• Online Access: https://hdl.handle.net/10356/146996
• Institution: Nanyang Technological University

Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identified in patients with autosomal dominant Parkinson's dis...